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The tripeptide structure of GSH suggest its potential role as a neuroactive molecule

Notably, PAC is a particular NSAIDs with no or negligible anti-inflammatory and antiplatelet activity ( Glutathione Levels and COVID-19 An interesting breakthrough in the comprehension of COVID-19 pathogenesis may derive from three independent articles published between April and May 2020 pointing to the importance of reduced glutathione (GSH) cellular levels and integrity of the related antioxidant routes in COVID-19 pathogenesis ( The first article is a commentary which proposes glucose-6 phosphate dehydrogenase (G6PD) deficiency as a factor contributing to COVID-19 morbidity and mortality ( null genotypes, known to be associated to an increased risk of several oxidative stress-related multifactorial diseases ( Over the following months further articles strengthening this view have been published: a PubMed search with the terms COVID-19 AND glutathione retrieved 17 records since June 1 to September 1, 2020

It directly donates a reducing equivalent (a hydrogen electron) to these unstable molecules, neutralizing them into harmless water and oxygen before they can wreak havoc on the cell's delicate machinery